前清刺客老吴隐姓埋名于药铺，却为守护单亲母女小茜和依依，被迫出手击杀黑帮一伙而暴露身份。幕后黑手向爷派杀手左轮抓住母女二人要挟并引出老吴。老吴救人不及受伤被捕，母女二人一死一伤。后药铺老板娘梅姨只身救出被囚的老吴却也中枪牺牲。两个与老吴关系最紧密的女性接连为他而死，沉痛之下他最终放弃十年隐忍，将所有悲愤化作一场怒杀——最终于惨烈搏杀后手刃宿敌左轮，并揭发幕后黑手向爷当年残害自己妻女的真相……
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